Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9722 |
YTX-465
|
Stearoyl-CoA Desaturase (SCD) | Metabolism |
YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂,抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。 | |||
T38278 |
9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid
|
||
9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice. | |||
T35448 |
10-Thiastearic Acid
|
||
Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics. |